Additional citations were retrieved from the bibliography of the articles identified in the initial search. The abstracts were then reviewed for relevancy based on the inclusion/exclusion criteria. These were initially screened by title and all duplicates were removed. Results: The electronic database search retrieved 637 relevant citations. Predefined keywords were used to perform the database search in MEDLINE, EMBASE, and International Pharmaceutical Abstracts to identify reviews, reports and guidelines on the assessment, prevention and monitoring of drug-induced QTc prolongation with an emphasis on psychotropic medications and management in the psychiatric population. Methods: A review of the literature was undertaken. Objectives: The objective of this project was first to review the literature, which describes guidelines and recommendations for the assessment and management of drug-induced QTc prolongation, and then to design an algorithm to be used by pharmacists working closely with mental health professionals or who provide care to psychiatric patients. Although this information is often accessible, advising how to identify, assess, manage, and refer psychiatric patients at risk for drug-induced QTc prolongation is more challenging. Pharmacists are often consulted about medications which are known to prolong the QTc interval. 1Division of Clinical Pharmacy and Practice, College of Pharmacy, Qatar University, Doha, Qatar 2Pharmacy Department, Grey Nuns Community Hospital, Edmonton, AB, Canadaīackground: Certain psychotropics and a number of other medications used to treat medical conditions in psychiatric patients can increase the risk of prolonging the corrected QT (QTc) interval on the electrocardiogram, which puts patients at risk of life-threatening ventricular arrhythmias such as torsades de pointes.
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